Why Are So Many Newborns Still Being Denied Pain Relief?

Why Are So Many Newborns Still Being Denied Pain Relief?

In 1985, a premature baby was born in Maryland who needed surgery to tie off a dangerous blood vessel near his heart. The newborn, Jeffrey, died weeks after the procedure. His family learned afterwards that none of the procedures had been performed with analgesics; the only drug administered was a muscle relaxant. The press ran with the story, alerting Americans to the grim realisation that hospitals in the United States routinely operated on critically ill premature babies without giving them painkillers. "Most adults would be shocked if they saw what was done to children in hospitals without anesthetics," said Myron Yaster of Johns Hopkins in a subsequent Baltimore Sun article. "It's like roping and holding down a steer to brand it." Jeffrey's parents took action, leading to the 1987 declaration by the American Academy of Pediatrics that it was no longer ethical to perform surgery on preterm babies without anesthetics.

It's been nearly 30 years since the AAP declaration, but to this day, many procedures are performed on newborns without the benefit of analgesics. That's largely because of an enduring misconception in the medical community that newborns don't feel pain like adults.

Two years ago, a review of neonatal pain management in intensive care units (NICUs) in Europe found that newborn babies experience 11 painful procedures each day on average, but that 60 per cent of these babies weren't receiving any kind of pain relief. That's in keeping with common practice in the United States and Britain, where less than 35 per cent of infants undergoing painful procedures received any kind of analgesic to manage their pain. These procedures ranged in scope from the very mild, such as taking blood samples, to more invasive interventions, like chest tube insertions and circumcisions.

And the latest scientific evidence shows unequivocally that newborns not only experience pain, but that they experience it more intensely than adults. The medical community is proving slow to respond. And experts who speak out continue to face ridicule and censure.

Why Are So Many Newborns Still Being Denied Pain Relief?

Groundbreaking cardiac surgery for newborns in 1945 at Johns Hopkins. A nurse can be seen at the head of the table administering anaesthesia. Via The Alan Mason Chesney Medical Archives of The Johns Hopkins Medical Institutions.

Prior to the Second World War, surgeries performed on babies were often fatal. Physicians began to administer anaesthesia to infants in the 1940s and 1950s, but many infants experienced cardiac arrest and brain damage. Their tiny bodies couldn't sustain the metabolic and circulatory effects of these potent anaesthetics. Discouraged, surgeons started to wonder if anaesthesia for infants was even necessary.

It was also around this time that clinical psychologist Myrtle McGraw began to study the reactions of newborn infants to various stimuli, including pinpricks. Her experiments, conducted at Babies Hospital in New York City, showed that babies who had been fed and swaddled did not react to pinpricks, and that those who were awake did not have a specific response to pinpricks on parts of the body that were stimulated. In her subsequent research paper, McGraw assumed that the infants' more generalised startle response was not a specific response to pain, and concluded that babies don't perceive pain — at least not in the way that adults do. Her research was integrated into medical textbooks and became standard.

Over the next three decades, it was common to perform surgery on newborn infants using no anaesthetics or pain relief. To prevent babies from squirming and thrashing around, surgeons administered neuromuscular blocks (muscle relaxants). Doctors essentially paralysed their patients for surgery.

"What many people failed to acknowledge in the years following McGraw's work was that pinpricks are a minor injury, or that they may not even cause any tissue injury at all," said Kanwaljeet J. S. Anand, professor of Pediatrics and Anesthesiology at the Stanford University School of Medicine, and a pioneer in the study of infant pain. "Surgical operations, on the other hand, they're a lot more invasive."

The situation started to change in the late 1970s and early 1980s, culminating in the AAP decision. But the idea that babies don't really feel pain persisted, and doctors continued to be wary of using painkillers on babies. "Neonatal circumcision is one common surgical procedure," Anand said. "The use of analgesia or sedation or local anesthetic is not widely prevalent for this." Other procedures routinely performed on infants include immunisations, blood extractions and the placement of IV catheters and chest tubes, usually without analgesia.

Why Are So Many Newborns Still Being Denied Pain Relief?

A neonatal intensive care unit in Hawaii. Via Kapi'olani Medical Center

To get a sense of what routinely occurs in hospitals today, we talked to a bedside nurse who works at a NICU and asked to remain nameless. She requested anonymity for fear of losing her job; her opinions on infant pain are not shared by many of the doctors she works with.

"I've heard doctors say that they don't believe babies — especially premature babies — feel pain the same way as adults because their nervous system (and/or musculoskeletal system) is not fully developed," she explained to Gizmodo in an email. "Clinically this does not seem to be the case."

Recently, her unit had an infant patient whose brain stopped developing during the eighth week of pregnancy. Fluid had accumulated in the baby's ventricles, putting pressure on her brain. Yet the doctors didn't think she could be in pain because her brain was so underdeveloped. The nurse also cited instances of doctors skipping pain medication for children who have chest tubes, are intubated or are uncomfortable because they have an accumulation of excess fluid.

"Chest tubes are very painful," she said. "Endotracheal tubes are uncomfortable — just imagine a rigid rubber tube shoved down your throat trying to breathe for you. Our ventilators are quite smart and try to breathe with the child as much as possible so that they are not fighting the vent. This doesn't always work. Babies will be sedated if they are fighting the vent so much that we cannot properly ventilate them."

Why Are So Many Newborns Still Being Denied Pain Relief?

A newborn sleeping in an incubator. Via Zerbey CC BY-SA 3.0.

The doctors in her unit don't administer pain relief for gastroschisis, a condition whereby an infant is born with their bowels, and sometimes other organs, on the outside. To treat it, a medical team will put the bowels and organs in a pouch and hang it above the infant, so the pouch can slowly descend into the abdominal cavity. But because the organs develop outside of the body, they must be put back in slowly so that the cavity has time to expand. Sometimes, surgeons will assist the process by slowly pushing a little intestine inside.

"We like to give pain medication for this procedure and our neonatologists are usually pretty good at ordering this, but the surgeons don't like it," the nurse said. "They are of the opinion that the procedure doesn't hurt because the intestines do not have pain receptors. However, the skin that has to stretch to accommodate these organs do have pain receptors — and just imagine if someone put a heavy weight on your stomach, it wouldn't be pleasant. Our patients do not tend to tolerate the procedure very well without pain medication. Their PIPP scores are often quite high."

PIPP refers to the Premature Infant Pain Profile (pdf), a behavioural measure of pain for premature infants. Other similar scales exist, including the Neonatal Infant Pain Scale (NIPS), Pain Assessment in Neonates (PAIN), the Neonatal Assessment of Pain Inventory (NAPI) and many others. But there's a surprising lack of standardisation between them.

Indicators on the PIPP profile include gestational age, changes to behavioural state, heart rate, oxygen saturation and physical indicators such as nostril flaring, bulging brows and eye squeezing. But even armed with the PIPP, nurses have trouble translating behavioural cues to pain.

Why Are So Many Newborns Still Being Denied Pain Relief?

PIPP illustration. Via Royal Hospital for Women.

"Most normal baby behaviours are reflexive, including feeding," said the nurse. "Reflexes are so primitive that it is difficult to assess the cognitive status of these children. If we can't even discern cognitive status in these infants, how can we be expected to appropriately assess something as subjective as pain?"

Anand said he wasn't surprised by the nurse's experiences. "I think these surgeons are not well informed about the nature of pain," he said. Preterm babies in particular are at risk, as they're the ones most likely to be exposed to the greatest number of painful stimuli in the NICU. They also happen to be the smallest and sickest.

Since babies can't talk, behavioural measures of pain are important, even if they're limited and open to interpretation. Pain can be judged by looking at changes to physiology, and later by looking at changes in psychology, such as an aversion to certain stimuli.

But neurological evidence is emerging as well. A pioneering study conducted at Oxford University last year, led by Rebeccah Slater, used fMRI to scan the brains of 10 healthy infants aged one to six days old, and 10 healthy adults aged 23 to 36. The researchers poked subjects' feet with a special device that retracts upon contact. "It's a bit like poking the baby with a blunt pencil,"said study co-author and Oxford postdoctoral researcher Caroline Hartley.

Why Are So Many Newborns Still Being Denied Pain Relief?

Brain scans showing activity in adults and babies when poked with a special retracting rod. Red-yellow coloured areas show active brain regions. Via University of Oxford.

The team found that babies respond in a very similar way to adults. In fact, 18 out of the 20 brain regions activated in adults were also activated in babies, including brain regions that tell us where a given stimulus is on the body, and those that tell us a stimulus is unpleasant. The brains of the newborns exhibited the same response to a weak stimulus as the adults did to a stimulus four times as strong, suggesting that babies might be more sensitive to pain that adults.

Scientists at the Goldsmiths InfantLab at the University of London have shown that babies feel tickles differently from adults. This study, published in Current Biology, describes the phenomenon as "tactile solipsim", a developmental stage in which babies are incapable of relating touch to an object or event outside of themselves. As lead author Andrew Bremner explained in Brain Decoder, "They just feel the touch as a touch on their body and that's all. To me this idea of what it would be like to be a baby feeling a touch is quite strikingly different to our own realities."

Why Are So Many Newborns Still Being Denied Pain Relief?

There are consequences to ignoring infant pain. A 2003 study published in the British Medical Journal listed several, including immediate effects like irritability, fear and sleep disturbance; short term effects such as a diminished immune system; and long term effects like ongoing memory of the pain and even developmental delays. Study after study has shown that babies who are given pain relief consistently exhibit better medical outcomes.

So why the reluctance? There are multiple factors at play. According to Anand, there's "a somewhat extravagant concern" about the side-effects or toxicities of pain relieving agents in newborns. He said there is still a "diehard notion" among some practitioners that babies should not be given painkillers.

Analgesic drugs do have side-effects, and if used indiscriminately they can cause severe problems for babies. Exposure in the absence of pain will change a baby's brain development, and can cause a newborn to develop a dependence on the drugs.

"So herein lies the rub," said Anand. "We have to use our clinical acumen to judge the degree of pain that is being produced by a particular procedure, and use analgesia in a judicious way to take away that degree of pain, or at least lessen the intensity of that pain. I'm all for the judicious use of analgesia and for avoiding large or prolonged doses of drugs."

Changing medical culture around the treatment of newborns won't happen overnight, but it's not an intractable problem. Pain management should be incorporated into medical training, and workshops and online resources should be made available. A recent study done in Europe found that countries with nationally accepted guidelines, such as Sweden, the Netherlands and France, did much better in treating neonatal pain than those without. The US and Canada are lagging behind. In 2001, an international consensus group on neonatal pain tried to get the ball rolling on the development of standardised national guidelines, but not much has been done since then.

When Anand began his work in the 1980s, he found that people were eager to deny and denigrate the information he was presenting.

It was as if the medical community as a whole was experiencing cognitive dissonance on the matter, afraid of having to confront the truth and go to the trouble of overturning standard medical convention.

"My career has taken a hit because of my commitment to getting people to pay attention to this aspect of newborn care," Anand said. "Grant funding has also been very difficult. Obviously, I'm committed to the babies whose suffering needs to be acknowledged."

[ Sources: Sezgi Goksan et al., 2015: "fMRI reveals neural activity overlap between adult and infant pain" | K. J. Anand et al., 1987: "Pain and its effects in the human neonate and foetus" | D. W. Roofthooft et al., 2014: "Eight years later, are we still hurting newborn infants?" [Goldsmiths InfantLab 1, 2 [P. Matthew et al., 2003: "Assessment and management of pain in infants" [American Academy of Pediatrics ]] Top image: Jim Cooke


Comments

    The real problem is that to admit that premature babies feel pain would have major implications for abortion.

      Even a viable premature baby is not a foetus, how about you look into the development of the nervous system before you equate the two. Even if they were the same and even if there is a few moments of pain before the foetus is terminated completely there is not going to be any ongoing impact on an actual human being.

      This great understatement of the mutilation of male genitals is where the major implications should occur.
      “Neonatal circumcision is one common surgical procedure,” Anand said. “The use of analgesia or sedation or local anesthetic is not widely prevalent for this.”

      In my opinion there should be no procedures done on a child that is not necessary for their survival, excepting some corrections that get more difficult the older a person gets, until they are old enough to participate in their own pain management.

        "Mutilation"? That's going a bit far.

          Not really. Removing a body part for what reason? Because it was done to their daddy?

            It's just loose skin.

              So we should remove loose skin from anywhere on the body for no reason? That makes no sense.

              Your earlobes are just loose skin, feel like loping those off?

              "It's just loose skin"

              Lol, yes, if its loose and on the body, cut it off. Don't worry about the few million years of evolution that got it there. Ahh, sadly evolutionary intelligence didn't weave its magic on all of us did it.

                I don't think you understand evolution...
                1. Human penis foreskins haven't been around for a few million years.
                2. Evolution isn't a process that leads to perfection, it's just simple change over time.

                  Im no expert, but Ive read a lot of Dawkins. Are you saying that the foreskin got there without evolution? So how did it get there? Let me guess...ET or god?
                  1. Human penis foreskins haven't been around for a few million years.
                  Actually it has been around for a few million years, do some reading on the link provided below. Evolution has impacted everything about us, you can't remove parts of your body from the "process" of evolution, its all in or out Im afraid.
                  2. Evolution isn't a process that leads to perfection, it's just simple change over time. At what point did I mention perfection? Im again, well aware that there is little to no affiliation between perfection and evolution. Perfection is an opinion, not science. Im not discussing its role in being an advantage to the species, Im saying that it got there through a process, like your fingers, skin colour. (Im talking about evolution in general, macro, micro)
                  The reason we cut off foreskins now, is through our opinions. Yours is to cut it off, but for no reason other than opinion, not science. In the past we practised it widely because we were too stupid to understand what hygiene was, fact, science has once again stepped in and shown us how advantageous a little soap and water can be. Do some reading, there are some great studies which show its importance, and role in physiology, which can make it advantageous to species in different environments.
                  https://en.wikipedia.org/wiki/Foreskin
                  Perhaps you should do some reading on evolution, can I suggest The Selfish Gene and The Blind Watchmaker by Dawkins, both amazing books.

                  Cheers

                You still don't quite get it-
                1. I said "human penis foreskins": humans did not evolve millions of years ago. Our appearance was more recent, so they're not " millions of years" old.
                2. You talked about foreskins the product of evolution as if that makes them more important. It's irrelevant how they got there.
                Your arguments are pointless and silly.

                  Ahhh, humans are primates? Or do you class us as some sort of "other" species? Primates have been evolving for the last few million years.
                  I didn't talk about foreskins being important, "you" however, misinterpreted it that way. Thats not what I meant at all. My arguments were no less silly then saying..."its just loose skin".

      No, because babies are not developed that far when they are typically aborted, it's a supremely, amazingly different thing from a premature baby.
      Very late term abortions are only typically performed when the mother's life is in danger.

        You would probably be horrified to know the truth on this matter.

          I know enough about real abortion, not the fantasy horror stories they fool "pro-lifers" with.

          Then present the truth you speak of then, And something thats not from the bible or a fundamentalist christian pro life site.

            Sorry I tend to get my information in Science from scientific texts, and personal experience.. as a Professional.

            That quite a lot of late second trimester termination happen, and the infant must often be euthanased before or after delivery. Even If it is late enough for the infant to have a decent hope of survival if the correct facilities are provided. We must remember that the age at which a foetus is deemed to have any rights is merely a legal construct and varies from country to country, with little bearing on survivability IF a pre-term delivery.

            A human foetus at any time after 12 weeks of gestation is remarkably fully developed and has no similarity with a lifeless blob which the pro-death lobby has many believing.
            It is actually not known how early a pre-term foetus is capable of surviving in modern apparatus, [I think 22 weeks is the earliest], of course a live foetus delivered at 28 weeks thrown out on the street with no care (or the garbage disposal) will be dead in a short while.

            [OO]"it's a supremely, amazingly different thing from a premature baby."
            Not when you look at the pictures it isn't.

            A 2 weeks abortus IS just a mess of blood and conception products, at 11-15 weeks it is a well developed, though nonviable human, by 20 weeks it probably should be given a chance.

            Last edited 06/02/16 3:49 pm

            Why do you mention the bible?
            Do you hold Herodotus, Archimedes, and Plato in the same disrespect?

    I went into this article thinking there might be a shortage of analgesics that have actually been approved for use in babies (because of ethics of performing clinical trials on this patient population etc). I was pretty appalled to discover that it essentially boils down to because doctors don't think they feel pain.

      I know what you mean. Before this article I would never have thought that they would operate on anyone, no matter how old, without anaesthetic!! This is appalling!!

      Sadly, it doesn't actually surprise me. Many things are done in health simply because it suits the doctors better, to the detriment of the patient. For instance, it's best for mothers to give birth squatting to enable gravity to assist with the process. But they are routinely put on a bed in a compromising position so that the doctor doesn't have to bend over...

        Squatting is also a not so neat-nor-pretty-nor-safe-for-the-baby means of testing an epidural...

    I thought it may have been because of all the risks involved with using general anesthesia. If when it goes wrong it can kill a adult. Getting it right on a newborn would appear to be harder. Plus there are other factors at play, when I had my punctured lung drained (via a 1/4" plastic tube hammer from my arm pit through my ribs into my lung). It was only done with a small amount of local as my vitals were so low that a more powerful or general anesthetic would have been to dangerous to use.

    The Abortion debate, clouds the issue a little.
    In Broad strokes, the embryonic stage lasts from fertilisation to ~8 weeks (10 Weeks LMP, its debatable amongst professionals)
    From this point until BIRTH (at whatever age) the "baby" remains classified as a Foetus, it isn't a "baby"/neonate until it is delivered, we just call them "babies" because mothers don't like to hear the word "foetus" (sounds a bit rude) used of their progeny.

    There is NO neurological difference between a 22 Week Foetus and a 22 week Pre-term viable (or unviable) Baby (the ductus arteriosus and foramen ovale may have closed - does this change immediately change them into a sentient creature? It does change them into air breathers). The foetus is inside the mother, the neonate is outside the mother, that's all the difference.

    Any (thinking) person who works with in-utero "children" could demonstrate to any interested party, that a "baby" in the womb, well before 20 Weeks Gestation (18 weeks post fertilisation) respond to stimuli, using the rationale in this article, if a baby/foetus can respond to stimulus then it can sense pain.

    So foeticide by injection of ethanol into a foetal heart at 14-24 weeks could be deemed unethical if the foetus can be shown to respond to stimuli ie. a sentient human being. This could decimate the obstetric industry.
    (A 11-12 week foetus even responds to stimuli, this fact is used by clinicians to "get the baby to change position" during an examination, if the foetus is in a position which limits imaging/measurements.)

    The first comment regarding the Foetal Pain, versus the right to life, has a point. In many "developed countries" elective terminations are legal up to 20-24 weeks gestation:
    "Under UK law, an abortion can usually only be carried out during the first 24 weeks of pregnancy" http://www.nhs.uk/conditions/Abortion/Pages/Introduction.aspx

    A foundation of the law resides on the opinion that rights aren't attributable to a foetus at an age where it wouldn't be viable if born, therefore the maternal wishes are to be respected irrespective of the harm caused to the foetus. The use of "undeveloped nervous system" etc (It is true the lungs are not developed enough to sustain life in the late 2nd trimester, but medical science has improved using techniques which allows younger than previously possible infants to survive)) just allows the professions to manage objectors (right to life-rs) with some "evidence based science" even if their premise may be misconstrued.

    That a Newborn baby can feel pain shouldn't be an issue (not up for debate, it is easily tested, let the science conclude on that), but the fact that they won't develop a memory of the event seems to sway Drs towards not using analgesia for simple procedures, to lessen the likelihood of any possible HARMFUL side effects (many drugs are not tested for effects on young children or pregnant women for ethical reasons).

    Also this article does happen to be created to give voice to radical dissenters, and colours the facts/opinions accordingly.

    Remember opinion doesn't come into science, or does it?
    (The scientific method leaves no room for opinion, it merely tests hypothesis and reports findings, when opinion enters science leaves the room, everything else is belief/faith [evidence based or not].)

    TLDR, additional info above, mainly in response to some commenters opinions.

    Last edited 05/02/16 4:09 pm

      Remember opinion doesn't come into science, or does it?
      I sure hope not!
      Science is my life raft in an ever growing sea of dribbling shit that is "opinion". Every opinion is logically false. And like arseholes, we all have one.
      Great reply.
      Cheers

        Opinion shouldn't come into science but it does, in nearly every article and debate written by a scientist trying to make sense of their profession to the general public.

        When scientists get heated on certain topics, one can be fairly certain that they have strayed from the science into the world of opinion, trying to make sense of something which is untested, untestable, or non-falsifiable. They should just admit, there are questions, unasked, unanswered, and even questions unanswerable, but we never know which these are until we ask the questions.

          Agreed. But, we are all humans none the less, and affected by emotion. Evolutionarily these give way to unique survival traits (love-care, greed-eat etc), but they will always affect our judgment, and our perception of the truth, even scientists. It sucks to be wrong! Thats the short of it. When you've constructed "a reality", its hard to let go of. You should always be prepared to have the ground ripped form under you, for a stronger floor. Lets hope we survive the learning process lol

    I too am somewhat horrified to discover that the reason why painkillers are not given is that, essentially, doctors think they don't matter.

    There are somewhat justifiable questions concerning safe dosages that could be raised (and the ethical problems in testing what comprises a safe dosage) but it sounds like the debate isn't even reaching that point.

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