Graphene’s Newest Trick Is Fighting Deadly Blood Clots

Graphene’s Newest Trick Is Fighting Deadly Blood Clots

Man, graphene is shaping up to be a real wonder-material (if it can make it out of the lab and into the real world). Chalk up another future use: a coating that eliminates blood clotting in medical devices by kickstarting the body’s natural clot-fighting mechanism that lasts way longer than anti-clotting drugs. Cool!

In a paper published in this week’s Nature Communications, researchers explained how molecules of hemin and an enzyme called glucose oxidase can be mounted on a one-atom-thick graphene lattice. When it contacts the blood stream, the active molecules in this coating react with sugars in the blood to kick off production of nitroxyl, a substance with natural anti-clotting properties.

So what’s the benefit of this wonder-coating? In testing, a plastic film coated with this material effectively eliminated clotting for three days — by comparison, standard anti-clotting drugs require multiple doses a day to maintain therapeutically effective levels. Controlling clot formation on synthetic surfaces, like artificial heart valves or the tubing used for dialysis, is a major concern. Effectively blocking clotting with a super-thin coating that doesn’t need to be replenished could mean less complications and a reduced need for blood thinning drugs.

Of course, as with all things graphene, there’s a long road separating the laboratory from general use. You won’t be seeing graphene-coated medical equipment any time in the near future. But if this technique pans out, perhaps every hospital device will pack the power of graphene. [Nature Communications via TheScientist]

Picture: Teng Xue and Nathan Weiss