It's easy to lose your sense of scale when thinking about the massive oil spill spreading across the Gulf of Mexico, and I'm not sure this photo, taken from the ISS, will help.
Soichi Noguchi, a JAXA astronaut currently floating around the ISS, has been raining down various photos of the Earth's surface for quite some time now, via his Twitter account. There's no context provided with the picture, so it's hard to be sure which part of the photo is oil, and which is water. Generally, oil has photographed as lighter than water from space, so I'm guessing it's the terrifying, overwhelming lower left section.
(Also, in case you were wondering, this shot was taken with a Nikon D3S. EXIF data, from SPACE!) - Thanks, Anthony!