Well, it's not clear in Businessweek's summary of the report, but iSuppli is assuming—rightfully—that many under-the-hood components, like camera sensors and wireless antennae, will be similar (if not identical) to what's currently found in products from Apple and HTC, so this could just be an effect of falling component prices. The Pre is an innovative, fresh handset, but mostly on account of its software. Under its skin, it's more-or-less just another 3G, multitouch, Wi-Fi-enabled phone, released almost a year after its closest equivalent. So it should cost less.
Another possibility: iSuppli doesn't have a Pre—or even a detailed component list—and although their prior estimations have been right on the nose, they could have just missed the mark entirely. [BusinessWeek]